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Acquired Platelet Function Disorder


Overview, Causes, & Risk Factors

An acquired platelet function disorder refers to an abnormality in the clotting ability of the platelets that develops sometime after birth. Platelets are a type of cell found in the blood that help the blood to clot. A number of disorders can affect the function of platelets.

What is going on in the body?

Platelets, along with a number of other substances in the blood, help blood to clot. When a person cuts him- or herself, blood must clot, or turn solid, to stop the bleeding. When platelets lose their ability to function for any reason, abnormal bleeding and bruising may occur.

What are the causes and risks of the condition?

There are many possible causes of acquired platelet function defect. Common causes are as follows:

  • certain cancers of the blood, such as multiple myeloma and polycythemia vera
  • long-standing kidney failure, known as chronic renal failure
  • medicines, including aspirin, penicillin, and nonsteroidal anti-inflammatory drugs, which are called NSAIDs
  • open heart surgery
  • severe liver disease, such as cirrhosis
  • systemic lupus erythematosus, which is an autoimmune disorder where a person's immune system attacks his or her own body for unknown reasons

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