Treatment is directed at the cause, if one can be found. A man may be given antibiotics for a short time in case there is an infection. A man with cancer or urethral strictures may need surgery.
Antibiotics may cause allergic reactions, stomach upset, or headaches. All surgery carries a risk of bleeding, infection, and other complications.
Many men continue to have occasional episodes of blood in their semen. Others may only have it once. Treatment doesn't seem to affect this.
A man with a known cause for the blood usually gets better with treatment. After treatment, most men have no limitations on activities.
The man can monitor his semen at home for further episodes of bleeding. Changes or response to treatment can be reported to the doctor. Other monitoring is related to the cause. For example, a man who takes a blood thinner such as warfarin usually has regular prothrombin time, called PT, blood tests. Any worsening symptoms should always be reported to the healthcare provider.