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Creatinine Clearance


Overview & Description

This is a test of kidney function. It measures the amount of fluid filtered each minute by the kidneys.

Creatinine is made in the muscles and filtered through the kidneys. Almost all the creatinine released from the muscles makes its way into the urine as a waste product. Comparing the amount of creatinine in the blood with the amount of creatinine in the urine gives an idea of how well the kidneys are functioning.

Who is a candidate for the test?

Anyone whose has kidneys that may not be functioning well may need a creatinine clearance test.

How is the test performed?

This test is done with a urine sample gathered over a 24- hour period. The person should follow the specific instructions of the doctor on how to collect the urine sample. In general, this schedule is followed:

  • Day 1: The person urinates upon arising without collecting that sample. After that, he or she collects all of his or her urine for the next 24 hours in a special container.
  • Day 2: First thing in the morning, the person urinates into the container again. Then the individual covers it and refrigerates it. The sample is brought to the doctor, who will send it to the lab for analysis.
  • The person will also have a blood sample done so the blood level of creatinine can be measured and compared with that found in the 24-hour urine sample.


    Preparation & Expectations

    What is involved in preparation for the test?

    The person should request exact instructions from his or her doctor.


    Results and Values

    What do the test results mean?

    The healthy range of glomerular filtration rates for creatinine clearance is as follows:

  • males, 97 to 137 milliliters/minute (mL/min)
  • females, 88 to 128 mL/min
  • Abnormally low glomerular filtration rates may suggest:

  • acute tubular necrosis, which is kidney failure caused by damage to the kidney's tubules
  • heart failure
  • dehydration, which means the body lacks fluids
  • glomerulonephritis, which is an inflammation of the parts of the kidney that filter the blood
  • not having enough blood flow to the kidneys
  • shock, which is a life-threatening condition in which blood pressure falls too low to support life
  • obstructive uropathy, a kidney disease caused by blockage of the kidney's drainage tubes
  • acute nephrotic syndrome, where the kidneys stop being able to perform their filtering role
  • acute kidney failure
  • other types of kidney disease
  • Wilms tumor, a cancer of the kidneys generally seen in infants and young children

  • Attribution

    Author:David T. Moran, MD
    Date Written:
    Editor:Crist, Gayle P., MS, BA
    Edit Date:06/27/02
    Reviewer:Kathleen A. MacNaughton, RN, BSN
    Date Reviewed:10/15/02


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