The DPT vaccine may cause mild side effects. These include a slight fever, mild crankiness, and tenderness, swelling, and redness at the site of the shot. Acetaminophen can reduce fever and soreness, and can be given before the shot. A warm cloth over the shot site will help reduce soreness.
As with any medicine or vaccine, there is a slight chance of serious complications. Death has occurred in very rare cases. DPT causes complications in about 1 out of 1,750 immunizations. These include seizures and fever above 105 degrees Fahrenheit. Difficulty breathing or other signs of allergy may also occur.