The first step is to stop taking the antibiotic. Often this is the only treatment needed for diarrhea due to irritation. If irritation diarrhea is mild, the person may be asked to finish taking the antibiotic.
In diarrhea from infection, the antibiotic must be stopped. IV fluids may be used to treat dehydration and salt imbalances. A different antibiotic, usually metronidazole, can be given to kill C. difficile.
Metronidazole can cause stomach upset, nausea, and a metallic taste in the mouth. People should not drink alcohol while taking this medicine because the combination may cause severe abdominal distress and vomiting.
Most people get better as soon as the antibiotic is stopped.
Diarrhea due to irritation does not usually need to be monitored. The stool test for the C. difficile toxin can be used to monitor diarrhea from infection. Any new or worsening symptoms should be reported to the healthcare provider.