Fifth disease usually resolves on its own without treatment. Fever or joint pain may be relieved with over-the-counter pain medications such as acetaminophen. Aspirin should never be given to children, since it increases the risk of Reye's syndrome. Cool baths or compresses may help relieve itching from the rash.
Medications used to relieve pain or fever may cause stomach upset or allergic reactions.
The rash associated with fifth disease usually fades in one to two weeks. However, the rash may reappear following exposure to sunlight, heat, exercise, or stress. This does not mean that the illness has returned.
Any new or worsening symptoms should be reported to the healthcare provider.