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Glucose-6-Phosphate-Dehydrogenase Deficiency


Symptoms & Signs

What are the signs and symptoms of the disease?

Some people with G6PD deficiency have no symptoms at all. In others, the symptoms and signs can range from mild to severe, and may include:

  • newborn jaundice, an abnormal yellow color of the skin and eyes that is present at or shortly after birth
  • an enlarged spleen or liver
  • Hemolytic crisis is a group of symptoms that occur when many red blood cells suddenly die all at once. The symptoms that result include:

  • weakness
  • pain in the abdomen or back
  • jaundice
  • dark urine
  • fever and chills
  • severe fatigue
  • tachycardia, or a rapid heartbeat
  • low blood pressure
  • kidney failure, known as chronic renal failure
  • congestive heart failure, a condition in which the heart is unable to pump blood effectively throughout the body
  • shock

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