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Guillain-Barre Syndrome


Overview, Causes, & Risk Factors

Guillain-Barré syndrome, or GBS, is believed to be an autoimmune disorder in which the body creates antibodies against its own tissue. In people with GBS, the antibodies generally attack the myelin sheath, or lining of the nerves. They may also attack part of the nerves themselves.

What is going on in the body?

Guillain-Barré syndrome is thought to be an autoimmune disorder that is triggered by an infection, vaccination, or other factors. It causes a severe inflammatory reaction around the nerves. The myelin sheath becomes swollen. Impulses and messages cannot travel along the course of the nerve. In time, nerve impulses are blocked.

What are the causes and risks of the condition?

Most cases of Guillain-Barré syndrome are triggered by an infection. Two-thirds of the individuals with GBS have had an upper respiratory infection or gastrointestinal infection 1 to 3 weeks before weakness develops. Other infections that may trigger GBS include:

  • Chlamydia trachomatis\. Sexually transmitted disease refers to any contagious disease transmitted from one person to another during sexual contact. ',CAPTION,'Chlamydia');" onmouseout="return nd();">chlamydia infections
  • cytomegalovirus infections
  • hepatitis B
  • HIV infections, which cause AIDS
  • mononucleosis
  • Mycoplasma pneumoniae\ is a bacteria that causes infections in the respiratory system. Less often, it causes an infection of the central nervous system, heart, or skin. ',CAPTION,'Mycoplasma Infections');" onmouseout="return nd();">mycoplasma pneumonia
  • Some vaccinations may also trigger Guillain-Barré syndrome. These include:

  • flu vaccine
  • immunization against group A streptococcal infections
  • rabies vaccine
  • swine flu immunizations
  • Certain medicines have been identified as triggers for GBS. These include:

  • captopril, used to treat high blood pressure
  • danazol, a hormone derivative
  • gold, which is injected for diseases such as rheumatoid arthritis
  • heroin, a highly addictive illegal drug
  • penicillamine, which is used for chelation and to treat rheumatoid arthritis
  • streptokinase, used to dissolve blood clots
  • GBS may be triggered by a variety of other factors, such as:

  • blood cancers, especially Hodgkin lymphoma
  • pregnancy
  • surgery
  • No one knows for sure why these factors trigger Guillain-Barré syndrome in some people but not in others. More research is needed in this area.


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