Most people with histoplasmosis have mild cases that do not need to be treated. More serious cases can be treated with amphotericin B, fluconazole, or itraconazole.
Amphotericin B can cause chills, fever, low blood pressure, and kidney damage. Fluconazole and itraconazole may cause liver disease. Any of the medicines can cause allergic reactions.
People with HIV infection may need to remain on lifelong therapy to prevent relapse of the histoplasmosis.
Any new or worsening symptoms should be reported to the healthcare provider. Special blood tests can be used to detect relapse.