Diagnosis of acromegaly begins with a medical history and physical exam. It may take years after the first symptoms appear to diagnose acromegaly. This is because the changes occur so slowly. A blood test to measure the levels of human growth hormones, called HGH, is helpful in diagnosis. Many people with acromegaly develop high blood glucose levels, so this sign may prompt a doctor to investigate further.
Skull X-rays, a cranial CT scan, and a cranial MRI can be done to take pictures of the pituitary gland. They can help the doctor identify a problem with the pituitary gland. Bone X-rays can show thickening of the skull and the long bones of the body. X-rays may reveal some arthritis in the spine as well.