Histiocytosis is treated with corticosteroids, such as prednisone and methotrexate. These help reduce inflammation in the lungs. Other medications, such as cyclophosphamide, may also be tried. However, no therapy clearly helps this disease. Sometimes radiation therapy is used to treat bone lesions. A person who smokes should stop smoking.
Side effects vary depending on the medication, but may include allergic reactions.
Complications can occur with histiocytosis. A sudden collapse of the lung, known as atelectasis, is common. This disorder can lead to death due to lung or heart failure.
A series of x-rays and pulmonary function tests may be needed to see how the histiocytosis changes over time. Any new or worsening symptoms should be reported to the healthcare provider.