Multiple sclerosis, or MS, is a lifelong autoimmune disorder that can cause severe disability. An autoimmune disorder is one in which the body produces antibodies that attack its own tissue. People with MS produce antibodies that attack the white matter in the brain and spinal cord.
In multiple sclerosis, the myelin, or coating of nerve fibers, becomes inflamed in the brain and spinal cord. The inflammation damages the myelin, and signals cannot be passed along to the nerve.
About 70% of the individuals with MS have what is called the relapsing-remitting, or RR type, of MS. They have periodic relapses, or episodes where symptoms worsen. These relapses are followed by remissions, which involve partial or full relief from symptoms. The remaining 30% of people with MS have chronic, progressive disease. Although there are several subgroups, most individuals with chronic, progressive disease have a disease course that worsens steadily over time.
The cause of multiple sclerosis is not known. There are four major scientific theories about the cause of MS:
Some neurologists believe that MS develops because a person is born with a genetic predisposition to react to an environmental agent. When that person comes into contact with the agent, the contact triggers an autoimmune response that causes MS.