Treatment of nocardiosis includes the medication trimethoprim sulfamethoxazole (TMP/SMX). It must be taken for several months. If the person does not respond to TMP/SMX, other antibiotics can be added. These include ampicillin, erythromycin, and minocycline. The person may also need to have abscesses drained surgically.
Antibiotics may cause stomach upset, diarrhea, or an allergic reaction. Surgery can cause bleeding, infection, and allergic reactions to anesthesia.
Treatment of nocardiosis may need to be prolonged. The person needs to be aware of the importance of taking the antibiotic as prescribed, even after the symptoms have disappeared. It may take a long time for the person to feel better.
Frequent follow-up exams are very important. Blood tests may be used to monitor medication levels. Any new or worsening symptoms should be reported to the healthcare provider.