Pituitary Gland Deficiency - Hypopituitarism

The pituitary gland is located inside the skull. When this gland becomes less active than normal for any reason, hypopituitarism is said to occur.

What is going on in the body?

The pituitary gland is sometimes called the master gland of the body. It secretes many important hormones that have different effects on other glands in the body. When the pituitary gland is not working correctly, many things can go wrong in the body.

The danger of hypopituitarism is that levels of other key hormones may become too low. When thyroid hormone and adrenal hormone are extremely low, death may occur. The underlying cause of this condition, such as a tumor, may also have risks.

What are the causes and risks of the condition?

This condition has several causes, including:

What are the signs and symptoms of the condition?

A decrease in pituitary gland activity can result in low levels of:

How is the condition diagnosed?

A healthcare provider may suspect this problem based upon a person's medical history and a physical examination. Blood tests can confirm the diagnosis. Further tests, including special x-rays, may be needed to confirm the cause.

What can be done to prevent the condition?

Usually, nothing can be done to prevent this condition.

What are the long-term effects of the condition?

The decrease in pituitary activity may be permanent. If so, a person will need hormone medications for the rest of his or her life. If left untreated, very low levels of thyroid hormone or adrenal hormone can result in death. The underlying condition causing hypopituitarism may have its own long-term effects.

What are the risks to others?

There are no risks to others.

What are the treatments for the condition?

If possible, the underlying cause is treated. This may involve medications or surgery. Hormone replacement pills or injections are often required to boost low levels of certain hormones in the body.

What are the side effects of the treatments?

All medications have side effects, including allergic reactions and stomach upset. Hormone medications may cause the hormone level to get too high, which can be toxic to the body. Other side effects vary, depending on the medications used. When surgery is done, there is a risk of bleeding, infection, and allergic reaction to anesthesia.

What happens after treatment for the condition?

If the cause is successfully treated and the pituitary gland recovers, a person may not need further treatment. In most cases, though, this is not possible. Treatment with hormone replacement pills or injections are often needed for life.

How is the condition monitored?

The healthcare provider will monitor the functioning of the pituitary gland with periodic examinations and blood tests. Any new or worsening symptoms should be reported to the healthcare provider.

Author:Adam Brochert, MD
Date Written:
Editor:Coltrera, Francesca, BA
Edit Date:04/28/00
Reviewer:Gail Hendrickson, RN, BS
Date Reviewed:05/01/01

Sources