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Polycystic Kidney Disease


Symptoms & Signs

What are the signs and symptoms of the disease?

Signs and symptoms depend on the type of polycystic kidney disease. Children with the infantile form of PKD often have very large, malformed kidneys at birth. These children are usually critically ill because their lungs don't development correctly due to the PKD. Most affected children die in the first few days of life.

Children with the childhood form of PKD usually get symptoms before adulthood. They often have kidney failure which causes:

  • fatigue
  • nausea
  • vomiting
  • loss of appetite
  • itching
  • shortness of breath and difficulty breathing
  • In addition, these children often develop scar tissue in the liver that can cause liver failure or bleeding in the gut. Many children die from infections, kidney failure, or liver failure before or during early adulthood. Other children have a milder course and may even have no symptoms until adulthood.

    The adult form of PKD is the most common form. Signs and symptoms do not usually begin until adulthood and may include:

  • high blood pressure
  • blood in the urine
  • flank pain, or pain on the side of the abdomen
  • symptoms of kidney failure, which include fatigue, nausea, vomiting, and loss of appetite
  • itching, shortness of breath, and loss of the sex drive may also occur
  • repeated kidney infections or kidney stones
  • stroke, or lack of blood flow to the brain. This is caused by abnormalities in the arteries in the brain because of PKD. The arteries may form abnormal areas of widening, called cerebral aneurysms, which can burst and cause life-threatening bleeding into the brain.

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