The diagnosis of staphylococcal scalded skin syndrome is based on the history and physical exam. Culture samples are usually taken from the skin and inside of the nose. A soft swab is used to wipe these areas. The swab is then put in a container in which the bacteria are allowed to grow. If bacteria grow, they can be identified.
The diagnosis of SSSS is often confirmed with a skin biopsy. This involves scraping or removing a small piece of skin. The skin is then examined using a microscope.