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Symptomatic Gastrinoma - Zollinger-Ellison Syndrome


Symptoms & Signs

What are the signs and symptoms of the condition?

Most symptoms of Zollinger-Ellison syndrome are caused by the high level of stomach acid and the ulcers that develop as a result. Symptoms include:

  • abdominal distress, usually located in the area between the breastbone and the navel. The distress can be sharp, burning, or gnawing pain. It can also take the form of a sensation of pressure, fullness, or hunger. The pain typically develops 30 to 90 minutes after a meal. It is often relieved by food or antacids.
  • heartburn, or gastroesophageal reflux, caused by stomach contents splashing back up into the esophagus. This backflow causes pain or burning in the abdomen that travels up toward the throat.
  • diarrhea, which may include stools that float and are foul smelling
  • weight loss
  • bleeding in the stools. This may turn the stools dark red, black or make them sticky or "tarry."
  • nausea and vomiting. The vomit may contain blood or may resemble coffee grounds.
  • A common sign of ZES is abdominal tenderness, especially in the upper abdomen.


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