Early treatment of inflammatory bowel disease flare-ups may help prevent toxic megacolon. Medications to control diarrhea should be used with caution when the colon is inflamed or infected.
Toxic megacolon is life-threatening and may result in death. A person who develops a tear in the colon will require surgery. A colectomy, the removal of part or all of the colon, may be needed.
Toxic megacolon is not contagious and poses no risks to others.