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Trophoblastic Disease - Molar Pregnancy


Overview, Causes, & Risk Factors

A molar pregnancy occurs when a fetus is not able to fully form in the uterus. Instead, the fetal tissue becomes a tumor.

What is going on in the body?

In the US, a molar pregnancy occurs in 1 out of every 2,000 pregnancies. In this condition, fetal cells have an abnormal genetic makeup and form a tumor. This tumor, or "mole," can grow and even spread to other parts of a mother's body. In some cases, the mole may turn into a more dangerous cancer called choriocarcinoma.

What are the causes and risks of the condition?

In this condition, abnormal fetal tissue inside a woman's uterus forms a tumor. The exact reason this occurs is not known. Common risk factors for this condition include:

  • a recent full-term pregnancy, abortion, miscarriage, or ectopic pregnancy
  • a previous molar pregnancy
  • being of Asian or Mexican descent
  • being younger than 20 or older than 40 years of age
  • being poor
  • a diet that is low in protein, folate, or beta-carotene

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