Acrocentric chromosome: A chromosome (one of the microscopically visible carriers of the genetic material DNA) with its centromere (the ôwaistö of the chromosome) located quite near one end of the chromosome. The ôacro-ô in acrocentric comes from the Greek ôakronö meaning ôthe end.ö Humans have 5 pairs of acrocentric chromosomes. Down syndrome (trisomy 21) is due to an extra acrocentic chromosome, namely chromosome 21.A chromosome with a centromere near one end. Down syndrome (trisomy 21) is due to an extra acrocentic chromosome.