Callus: The word "callus" has several meanings: 1) A callus or callosity is a localized firm thickening of the upper layer of skin as a result of repetitive friction. A callus on the skin of the foot has become thick and hard from rubbing (as a result of repetitive friction). Calluses of the feet may lead to other problems such as serious infections. Shoes that fit well can keep calluses from forming on the feet. (2) A callus is also the word applied to hard new bone substance that forms in an area of bone fracture. It is part of the bone repair process.