Ichthyosis simplex

Ichthyosis simplex: A genetic skin disease, also called ichthyosis vulgaris, that is inherited as an autosomal (nonsex-linked) trait and is characterized by scaly (fishlike) areas of skin. The first scaly skin problems usually appear after 3 months of age. The palms and soles are often affected. Areas that tend to be spared include the axillae (the armpits), the antecubital fossa (the inside area at the bend of the elbow) and the popliteal fossa (behind the knee). A considerable proportion of persons with this disease have asthma, eczema or hay fever. The gene responsible for this disease has been mapped to chromosome band 1q21. The product of this gene is thought to be a substance called filaggrin (abbreviated FLG) which may act as the "keratin matrix protein" in cells of the stratum corneum, one of the layers of the skin.