Kaposi's sarcoma: A relatively rare type of cancer that develops on the skin of some elderly persons or those with a weak immune system, including acquired immune deficiency syndrome (AIDS). Kaposi's sarcoma is a type of vascular (angioblastic) cancer of the skin characterized by soft purplish plaques and papules that form nodules which often appear first on the feet and then slowly spread across the skin. The tumor was described by the late Austrian dermatologist Moritz Kaposi (Moritz Kaposi Kohn) (1837-1902).