_® ALLERGAN
PROPINE^®
(dipivefrin hydrochloride ophthalmic solution, USP) 0.1%
sterile

PROPINE^® contains dipivefrin hydrochloride in a sterile, isotonic solution. Dipivefrin HCI is a white, crystalline powder, freely soluble in water with an osmolality of approximately 250 - 330 mOsmol/kg.

Empirical Formula:

C₁₉H₂₉O₅N•HCI

Chemical Name: (±) -3,4-Dihydroxy–α– [(methylamino) methyl] benzylalcohol 3,4-dipivalate hydrochloride.

STRUCTURAL FORMULA:

Contains: Active: dipivefrin HCI 0.1%

Preservative: benzalkonium chloride

Inactives: edetate disodium; purified water; sodium chloride; and hydrochloric acid to adjust pH. The pH during its shelf life ranges from 2.5 - 3.5.

PROPINE^® (dipivefrin HCI ophthalmic solution, USP) is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response.

PROPINE^® ophthalmic solution is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and as a consequence, its penetration into the anterior chamber.

PROPINE^® is converted to epinephrine inside the human eye by enzyme hydrolysis. The liberated epinephrine, an adrenergic agonist, appears to exert its action by decreasing aqueous production and by enhancing outflow facility. The PROPINE^® prodrug delivery system is a more efficient way of delivering the therapeutic effects of epinephrine, with fewer side effects than are associated with conventional epinephrine therapy.

The onset of action with one drop of PROPINE^® occurs about 30 minutes after treatment, with maximum effect seen at about one hour.

Using a prodrug means that less drug is needed for therapeutic effect since absorption is enhanced with the prodrug. PROPINE^® ophthalmic solution at 0.1% dipivefrin was judged less irritating than a 1% solution of epinephrine hydrochloride or bitartrate. In addition, only 8 of 455 patients (1.8%) treated with PROPINE^® reported discomfort due to photophobia, glare or light sensitivity.

PROPINE^® (dipivefrin HCI ophthalmic solution, USP) is indicated as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma. Patients responding inadequately to other antiglaucoma therapy may respond to addition of PROPINE^®.

In controlled and open-label studies of glaucoma, PROPINE^® ophthalmic solution demonstrated a statistically significant intraocular pressure-lowering effect. Patients using PROPINE^® twice daily in studies with mean durations of 76-146 days experienced mean pressure reductions ranging from 20-24%.

Therapeutic response to PROPINE^® ophthalmic solution twice daily is somewhat less than 2% epinephrine twice daily. Controlled studies showed statistically significant differences in lowering of intraocular pressure between PROPINE^® and 2% epinephrine. In controlled studies in patients with a history of epinephrine intolerance, only 3% of patients treated with PROPINE^® ophthalmic solution exhibited intolerance, while 55% of those treated with epinephrine again developed intolerance.

Therapeutic response to PROPINE^® twice daily therapy is comparable to 2% pilocarpine 4 times daily. In controlled clinical studies comparing PROPINE^® ophthalmic solution and 2% pilocarpine, there were no statistically significant differences in the maintenance of IOP levels for the two medications. PROPINE^® does not produce miosis or accommodative spasm which cholinergic agents are known to produce. Night blindness often associated with miotic agents is not present with PROPINE^® therapy. Patients with cataracts avoid the inability to see around lenticular opacities caused by constricted pupil.

PROPINE^® should not be used in patients with narrow angles since any dilation of the pupil may predispose the patient to an attack of angle-closure glaucoma. This product is contraindicated in patients who are hypersensitive to any of its components.

Macular edema has been shown to occur in up to 30% of aphakic patients treated with epinephrine. Discontinuation of epinephrine generally results in reversal of the maculopathy.

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when PROPINE^® ophthalmic solution is administered to a nursing woman.

Safety and effectiveness in pediatric patients have not been established.

No overall clinical differences in safety or effectiveness have been observed between elderly and other adult patients.

Rabbit studies indicated a dose-related incidence of meibomian gland retention cysts following topical administration of both dipivefrin hydrochloride and epinephrine.

PROPINE^® (dipivefrin HCI ophthalmic solution, USP) 0.1%, is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with purple polystyrene caps as follows:

Note: Store in a tight, light-resistant container at 15° to 25°C (59° to 77°F).

Rx Only

Revised December 2005
© 2006 Allergan, Inc.
Irvine, CA 92612, U.S.A.
® marks owned by Allergan, Inc.
7592X
71738US11T