Statins may not protect against melanoma

DENVER, Nov 7, 2005 (UPI via COMTEX) -- A review of recent studies by Denver scientists reveals no clear evidence that cholesterol-lowering drugs can decrease the risk of melanoma.

Dr. Robert Dellavalle of the Denver Veterans Affairs Medical Center and colleagues say they found no significant difference in melanoma rates between people taking statins or fibrate medications and those taking neither class of the drugs.

The reviewers looked at 16 high-quality studies that included 62,197 people who had been examined for melanomas, a deadly and malignant skin cancer.

Statins and fibrates are the most popular drugs prescribed to lower cholesterol. Brand names for the drugs include Mevacor, Lipitor, Zocor, Abitrate and Lopid. Earlier research suggested the drugs might also have anti-cancer properties.

Dellavalle said the review does not exclude the possibility the drugs prevent melanoma, since there was a 10 percent decrease in melanomas among patients taking statin drugs. However, he said, "Until further evidence is established, limiting exposure to ultraviolet radiation remains the most effective way to reduce the risk of melanoma."

The review appears in the current issue of The Cochrane Library.

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