Molecule identified in prostate cancer

CHAPEL HILL, N.C., Nov 29, 2005 (UPI via COMTEX) -- University of North Carolina at Chapel Hill researchers say they have identified a molecule that stimulates the aggressive growth of prostate cancer.

The molecule, Ack1 -- a member of the growth-promoting tyrosine kinase gene family -- stimulates tumor formation, in part by signaling prostate cells to rid themselves of a tumor-suppressor protein. Normally, this suppressor protein would inhibit rapid cell growth by signaling the cell to destroy itself.

A report on the study, which appeared Nov. 15 in the journal Cancer Research, also points to Ack1 as a potential target for developing novel drugs against prostate cancer.

The study's senior author, Dr. Shelton Earp, a professor of cancer research, pharmacology and medicine, said tests of Ack1 demonstrate a profound effect on tumor growth in experimental systems. "It's a remarkable effect," said Earp. "Tumors grew more rapidly and invaded as if they were converted to advanced prostate cancer."

Another major finding involved an experimental drug developed by the National Cancer Institute called geldanamycin. In laboratory tests, the researchers found Ack1 activity could be inhibited by that drug through interference with the cells' molecular interactions, offering a target for treatment.

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