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Gamma-Glutamyl Transferase


Overview & Description

Gamma-glutamyltransferase, also known as GGT, is an enzyme that is found mainly in the liver. But it may also be found in the:

  • kidney
  • biliary tract
  • heart
  • brain
  • intestine
  • pancreas
  • spleen
  • Who is a candidate for the test?

    GGT levels are measured when a doctor suspects there is damage or disease in the liver or the biliary system.

    How is the test performed?

    In order to measure the amount of GGT in the blood, a blood sample is taken from a vein on the forearm or hand. First, the skin over the vein is cleaned with an antiseptic. Next, a rubber tube called a tourniquet is tied around the upper arm. This enlarges the veins in the lower arm by restricting blood flow through them. A fine needle is gently inserted into a vein, and the tourniquet is removed. Blood flows from the vein through the needle and is collected in a syringe or vial for testing in the laboratory. After the needle is withdrawn, the puncture site is covered for a short time to prevent bleeding.


    Preparation & Expectations

    What is involved in preparation for the test?

    Generally, no preparation is required for this test.


    Results and Values

    What do the test results mean?

    For men, the healthy values for GGT are 2 to 30 U/L.

    For women, the healthy range is 1 to 24 U/L.

    Abnormal levels of GGT can be found in the following conditions:

  • Alcoholism
  • Brain tumor
  • Diabetes
  • Gallbladder disease or other diseases of the biliary system
  • Heart attack
  • Liver diseases such as hepatitis, cirrhosis, or cancer
  • Mononucleosis
  • Pancreatitis
  • In addition, certain medicines that are used to prevent seizures such as tegretol, phenobarbital, and dilantin may be related to abnormal levels of GGT.


    Attribution

    Author:Melinda Ratini, DO, MS
    Date Written:
    Editor:Crist, Gayle P., MS, BA
    Edit Date:06/18/02
    Reviewer:Kathleen A. MacNaughton, RN, BSN
    Date Reviewed:06/13/02