General paresis is treated with high doses of penicillin for two or more weeks. Treatment early in the course of general paresis improves the mental and physical symptoms in about 40% of people.
Penicillin may cause allergic reactions, rash, or stomach upset.
Treatment halts the progression of the disease 40% to 50% of the time. Neurological problems improve in 30% to 40% of cases. The cerebrospinal fluid has to be rechecked to be sure that the Treponema organism is completely eliminated. Sometimes, the penicillin treatment has to be repeated. Any new or worsening symptoms should be reported to the healthcare provider.