There are no medical treatments for jet lag. Time will make jet lag disappear. When multiple time zones are crossed, such as in overseas travel, some people may want to use a mild sedative, sleeping pill, or melatonin to help "reset" their internal body clocks and get enough sleep.
Sedatives, such as diazepam, and sleeping pills, such as diphenhydramine, may cause prolonged sleepiness and may impair coordination. Melatonin may not work in some people and has caused sexual dysfunction in animals.
People gradually adjust to the new time zones and need no further treatment.
People can monitor their own symptoms of jet lag.