Testosterone is used to treat Klinefelter syndrome. Treatment must be timed carefully to coincide with the onset of puberty. If a learning disability is present, special education may be needed. Psychotherapy may be needed if emotional maturity and adjustment are problems.
If the timing of treatment is not balanced carefully, excessive growth may occur.
Treatment to maintain secondary sexual characteristics must continue throughout life.
Klinefelter syndrome itself is nonprogressive and does not need to be monitored. Effects of treatment for symptoms are monitored by growth measurements, x-rays, and hormone levels.