Practicing safer sex can eliminate some cases of Reiter's syndrome caused by a sexually-transmitted disease. Reiter's syndrome that follows food poisoning can be avoided by using good food-handling techniques.
Although most people recover completely from Reiter's syndrome, about 20% may be left with ongoing joint pain. Some individuals may develop chronic eye irritation known as uveitis,. Ten percent of the people who have Reiter's syndrome will develop heart valve problems, including aortic regurgitation. Rarely, the syndrome may cause severe arthritis and disability.
The original infection, which triggers Reiter's syndrome, can be spread to others. However, not all people will develop Reiter's syndrome as a result of the infection.