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Very-Low-Density Lipoprotein - VLDL


Overview & Description

Fat travels through the body in packages called lipoproteins. Very-low-density lipoprotein (VLDL) carries a type of fat known as triglycerides. This test measures the amount of VLDL in the blood. VLDL is usually measured with other lipoproteins, such as HDL and LDL. This is known as a lipid profile test.

Who is a candidate for the test?

The level of VLDL can help assess a person's risk of atherosclerosis, or clogged arteries. The test can also monitor how well medications prescribed to lower lipids are working.

How is the test performed?

The test is performed on a sample of blood. A needle is inserted into a vein, usually in the person's arm. Blood is then collected into a vial. A bandage and pressure are applied to the skin to prevent bleeding. The blood is sent to the lab for testing.


Preparation & Expectations

What is involved in preparation for the test?

The person needs to refrain from eating for 12 to 14 hours before the test. Drinking water is permitted. A low-fat diet should be followed in the 2 weeks before the test.


Results and Values

What do the test results mean?

Normal VLDL levels are 25% to 50% of total cholesterol. Higher amounts are linked to a higher risk of heart disease.

Reasons for high VLDL levels can include:

  • hypothyroidism, or an underactive thyroid gland
  • high alcohol intake
  • chronic liver disease, such as cirrhosis
  • multiple myeloma, a type of blood cancer
  • Cushing's syndrome, a condition caused by too much of a hormone called cortisol in the body
  • deficiency of an enzyme that breaks down lipids
  • Low levels of VLDL can result from:

  • an inherited tendency toward low LDL and VLDL levels
  • abnormally low levels of protein in the blood, called hypoproteinemia. This may be the result of malnutrition, bowel problems, or severe burns.
  • an hyperthyroidism, or an overactive thyroid gland

  • Attribution

    Author:Stephanie Slon, BA
    Date Written:
    Editor:Duff, Ellen, BA
    Edit Date:04/21/00
    Reviewer:Adam Brochert, MD
    Date Reviewed:09/04/01

    Sources

    Mosby's Manual of Diagnostic and Laboratory Tests, 1998, Kathleen D. Pagana and Timothy J. Pagana, Mosby, St. Louis.

    Triglycerides: Bad Actors or Innocent Bystander?, May 1998, Harvard Heart Letter.


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